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目的 分析原发性头痛患者人群中脑小血管病（cerebral small vessel disease,CSVD）和口腔黏膜病的相关临床指标，为防范两种疾病发生和进展提供依据。方法 回顾性分析2020年1月—2023年3月在甘肃省人民医院诊断为原发性头痛的98例中青年患者的临床资料，依据头颅MRI影像学评估分成CSVD组（25例）和非脑小血管病（NCSVD）组（73例），另回顾性分析同期50例健康中青年的临床资料，将其作为对照组，所有研究对象接受口腔黏膜病相关检查及实验室相关临床指标检测，比较三组的临床指标；筛选CSVD组的临床风险评估相关标志物，并通过受试者工作特征（ROC）曲线分析其预测能力；比较CSVD组和NCSVD组的口腔黏膜病发生率。结果 CSVD组患者年龄、低密度脂蛋白、C-反应蛋白、血磷、白细胞计数、中性粒细胞计数均高于对照组，25-羟基维生素D3低于对照组；NCSVD组总胆固醇、低密度脂蛋白、中性粒细胞计数均低于对照组，C-反应蛋白、25-羟基维生素D3、血钙、血磷、白细胞计数均高于对照组；且CSVD组患者低密度脂蛋白、C-反应蛋白、白细胞计数、中性粒细胞计数均高于NCSVD组，高密度脂蛋白、25-羟基维生素D3、血钙均低于NCSVD组（P<0.05）;CSVD组中AUC值从大到小依次为C-反应蛋白、白细胞计数、25-羟基维生素D3、中性粒细胞计数、低密度脂蛋白；NCSVD组中AUC值从大到小依次为25-羟基维生素D3、中性粒细胞计数、中性粒细胞计数、白细胞计数、C-反应蛋白（P<0.05）;CSVD组口腔黏膜病的患病率高于NCSVD组。结论 C-反应蛋白、白细胞计数和25-羟基维生素D3水平与脑小血管病发生密切相关，在口腔黏膜病的风险评估中具有潜在价值。C-反应蛋白、25-羟基维生素D3在脑小血管病风险评估中具有较高的预测价值。
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基本信息:
DOI：10.20256/j.cnki.zgdxbl.20250619.010
中图分类号:R743;R781.5
引用信息:
[1]冉海琼,祁晶,冯斌,等.原发性头痛患者人群中脑小血管病和口腔黏膜病相关临床指标研究[J].中国典型病例大全,2025,19(02):386-392.DOI:10.20256/j.cnki.zgdxbl.20250619.010.
基金信息:
甘肃省卫生行业科研项目（GSWSKY2020-77）
2025-01-03
2025
2025-06-17
2025-06-18
2025
1
2025-06-19
2025-06-19
2025-06-19